Vascular Endothelial Growth Factor Receptor-1 and Neuropilin-2 Form Complexes

1 Vascular Endothelial Growth Factor Receptor - 1 ( Vegfr - 1 ) and Neuropilin - 2 Form Complexes

Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2.

Neuropilin-1 (NRP-1) is a type 1 membrane protein that binds the axon guidance factors belonging to the class-3 semaforin family. In endothelial cells, NRP-1 serves as a co-receptor for vascular endothelial growth factor (VEGF) and regulates VEGF receptor 2 (VEGFR-2)-dependent angiogenesis. Although gene-targeting studies documenting embryonic lethality in NRP-1 null mice have demonstrated a cr...

Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability.

Neuropilin-1 (Npn-1) is a cell surface receptor that binds vascular endothelial growth factor (VEGF), a potent mediator of endothelial permeability, chemotaxis, and proliferation. In vitro, Npn-1 can complex with VEGF receptor-2 (VEGFR2) to enhance VEGFR2-mediated endothelial cell chemotaxis and proliferation. To determine the role of Npn-1/VEGFR2 complexes in VEGF-induced endothelial barrier d...

In vitro combination therapy of pathologic angiogenesis using anti-vascular endothelial growth factor and anti-neuropilin-1 nanobodies

Objective(s): Emergence of resistant tumor cells to the current therapeutics is the main hindrance in cancer treatment. Combination therapy, which mixes two or more drugs, is a way to overcome resistant problems of cancer cells to current treatments.  Nanobodies are promising tools in cancer therapy due to their high affinity as well as high penetration to tumor sites....

Neuropilin-1-Mediated Vascular permeability factor / Vascular endothelial growth factor (VPF/VEGF)-Dependent Endothelial Cell Migration